This report accompanies the United Nations University Center for Policy Research’s 2022 publication Stress Testing the UN’s Regional Prevention Approaches. This project was designed to take stock of UN approaches to regional prevention several years after the introduction of interconnected UN reforms, and assess how these reforms have translated into different approaches to prevention in three regions: Latin America, the Sahel and the Horn of Africa. . The main report found that expectations, strategies and capacities to implement the Secretary-General’s prevention agenda varied widely across the three regions and offered a series of cross-cutting lessons and recommendations for future strategy development. regional. The authors identify three models of prevention: (a) a “cascade model” in the Sahel, where regional strategies are meant to shape national plans; (b) a “net model” in the Horn, which aims not only to provide a platform allowing prevention actors to come together in a very broad and permeable configuration, but also to encourage them to move in the direction of greater consistency; and (c) an “alliance model” in Latin America built around coalitions that form based on calls between resident coordinators and regional actors for specific and specialized contribution and funding, taking into account the risks identified locally. This report argues that there could be broader application of some or all of these models in other contexts. Understanding their nuances will improve the design of future prevention strategies, identify multi-stakeholder partnership opportunities, and support programming at country and regional levels.